Analysts’ Top Healthcare Picks: Ikena Oncology (IKNA), PMV Pharmaceuticals (PMVP)
Ikena Oncology (IKNA): Analyst Matt Phipps from William Blair maintains a Buy rating on Ikena Oncology, which has a Moderate Buy consensus among analysts, despite Phipps' average return being -10.4%.
PMV Pharmaceuticals (PMVP): Analyst Yaron Werber from TD Cowen also holds a Buy rating for PMV Pharmaceuticals, which is near its 52-week low, and has a Moderate Buy consensus with an average return of 8.2%.
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PMV Pharmaceuticals Reveals New Interim Data on Rezatapopt Monotherapy from Ongoing PYNNACLE Phase 2 Trial for Various Solid Tumors with TP53 Y220C Mutation
Clinical Trial Results: Updated data from the Phase 2 PYNNACLE trial presented at the 2025 AACR-NCI-EORTC Conference showed a 34% overall response rate (ORR) across eight tumor types, with a notable 46% ORR in the ovarian cancer cohort.
Rezatapopt Overview: Rezatapopt (PC14586) is a first-in-class small molecule designed to reactivate the p53 protein in tumors with the TP53 Y220C mutation, with plans for a New Drug Application submission for platinum-resistant ovarian cancer in Q1 2027.
Safety Profile: The treatment was generally well-tolerated, with most adverse events being Grade 1-2, and a low discontinuation rate due to treatment-related adverse events (3.6%).
Future Directions: PMV Pharma aims to continue generating data to support regulatory strategies and enhance treatment options for patients with advanced solid tumors harboring the TP53 Y220C mutation.
PMV Pharmaceuticals' Small-Cap Cancer Drug Demonstrates Verified Efficacy Across 8 Tumor Types
Clinical Trial Results: PMV Pharmaceuticals released interim data from the Phase 2 PYNNACLE trial, showing a 33% overall response rate for rezatapopt in patients with advanced solid tumors harboring the TP53 Y220C mutation, with notable efficacy in ovarian (43% ORR) and endometrial (60% ORR) cancers.
Safety and Regulatory Plans: The treatment was generally well-tolerated, with most adverse events being mild. PMV Pharma plans to enroll additional patients for a New Drug Application (NDA) for platinum-resistant/refractory ovarian cancer by early 2027, following FDA feedback.
PMV Pharma Announces Encouraging Interim Results from Phase 2 PYNNACLE Trial
Positive Interim Data: PMV Pharmaceuticals announced positive interim results from the Phase 2 portion of the PYNNACLE study, showing a 33% overall response rate in patients with advanced solid tumors, particularly those with TP53 Y220C mutations and KRAS wild-type.
Ovarian Cancer Focus: The study reported a 43% response rate in the ovarian cancer cohort, with a median duration of response of 7.6 months, and the company plans to submit a New Drug Application for rezatapopt in platinum resistant/refractory ovarian cancer by Q1 2027.
Insider Sale: General Counsel & COO of $PMVP Sells 23,151 Shares
Insider Trading Activity: Robert Ticktin, General Counsel & COO of $PMVP, sold 23,151 shares of the company, representing about 19% of his holdings, and now owns 98,695 shares. In the past six months, there have been four insider sales with no purchases.
Institutional Investor Movements: In the latest quarter, 10 institutional investors increased their positions in $PMVP stock while 48 reduced theirs, indicating mixed sentiment among institutional stakeholders.
PMV Pharmaceuticals to Participate at Upcoming Investor Conferences
Company Announcement: PMV Pharmaceuticals, Inc. will participate in investor conferences on May 27 and June 5, 2025, with live audio webcasts available for both events.
About PMV Pharma: The company focuses on developing small molecule therapies targeting p53 mutations, which are present in about half of all cancers, leveraging over four decades of research in p53 biology.
HC Wainwright & Co. Reiterates Buy on PMV Pharma, Maintains $5 Price Target
Real-time Market Intelligence: Benzinga Pro offers the fastest and most accurate stock market alerts, helping traders stay informed and make winning trades daily.
Community of Traders: Over 10,000 serious traders are part of the Benzinga Pro community, gaining access to exclusive stories and insights from Benzinga reporters.
PMV Pharmaceuticals Reveals New Interim Data on Rezatapopt Monotherapy from Ongoing PYNNACLE Phase 2 Trial for Various Solid Tumors with TP53 Y220C Mutation
Clinical Trial Results: Updated data from the Phase 2 PYNNACLE trial presented at the 2025 AACR-NCI-EORTC Conference showed a 34% overall response rate (ORR) across eight tumor types, with a notable 46% ORR in the ovarian cancer cohort.
Rezatapopt Overview: Rezatapopt (PC14586) is a first-in-class small molecule designed to reactivate the p53 protein in tumors with the TP53 Y220C mutation, with plans for a New Drug Application submission for platinum-resistant ovarian cancer in Q1 2027.
Safety Profile: The treatment was generally well-tolerated, with most adverse events being Grade 1-2, and a low discontinuation rate due to treatment-related adverse events (3.6%).
Future Directions: PMV Pharma aims to continue generating data to support regulatory strategies and enhance treatment options for patients with advanced solid tumors harboring the TP53 Y220C mutation.
PMV Pharmaceuticals' Small-Cap Cancer Drug Demonstrates Verified Efficacy Across 8 Tumor Types
Clinical Trial Results: PMV Pharmaceuticals released interim data from the Phase 2 PYNNACLE trial, showing a 33% overall response rate for rezatapopt in patients with advanced solid tumors harboring the TP53 Y220C mutation, with notable efficacy in ovarian (43% ORR) and endometrial (60% ORR) cancers.
Safety and Regulatory Plans: The treatment was generally well-tolerated, with most adverse events being mild. PMV Pharma plans to enroll additional patients for a New Drug Application (NDA) for platinum-resistant/refractory ovarian cancer by early 2027, following FDA feedback.
PMV Pharma Announces Encouraging Interim Results from Phase 2 PYNNACLE Trial
Positive Interim Data: PMV Pharmaceuticals announced positive interim results from the Phase 2 portion of the PYNNACLE study, showing a 33% overall response rate in patients with advanced solid tumors, particularly those with TP53 Y220C mutations and KRAS wild-type.
Ovarian Cancer Focus: The study reported a 43% response rate in the ovarian cancer cohort, with a median duration of response of 7.6 months, and the company plans to submit a New Drug Application for rezatapopt in platinum resistant/refractory ovarian cancer by Q1 2027.
Insider Sale: General Counsel & COO of $PMVP Sells 23,151 Shares
Insider Trading Activity: Robert Ticktin, General Counsel & COO of $PMVP, sold 23,151 shares of the company, representing about 19% of his holdings, and now owns 98,695 shares. In the past six months, there have been four insider sales with no purchases.
Institutional Investor Movements: In the latest quarter, 10 institutional investors increased their positions in $PMVP stock while 48 reduced theirs, indicating mixed sentiment among institutional stakeholders.
PMV Pharmaceuticals to Participate at Upcoming Investor Conferences
Company Announcement: PMV Pharmaceuticals, Inc. will participate in investor conferences on May 27 and June 5, 2025, with live audio webcasts available for both events.
About PMV Pharma: The company focuses on developing small molecule therapies targeting p53 mutations, which are present in about half of all cancers, leveraging over four decades of research in p53 biology.
HC Wainwright & Co. Reiterates Buy on PMV Pharma, Maintains $5 Price Target
Real-time Market Intelligence: Benzinga Pro offers the fastest and most accurate stock market alerts, helping traders stay informed and make winning trades daily.
Community of Traders: Over 10,000 serious traders are part of the Benzinga Pro community, gaining access to exclusive stories and insights from Benzinga reporters.
