Kite Presents Yescarta Efficacy in Relapsed Large B-Cell Lymphoma
Written by Emily J. Thompson, Senior Investment Analyst
Source: Newsfilter
Updated: 10 hour ago0mins
- Efficacy Analysis: In the ZUMA-7 and ALYCANTE studies, Yescarta demonstrated an overall survival rate of 64.9% in patients with relapsed/refractory large B-cell lymphoma, significantly higher than the historical rate of 20%, indicating its potential as a second-line treatment.
- Treatment Response: After one year, the overall response rate for Yescarta was 46.6%, showcasing its ability to significantly shrink tumors in patients, further solidifying its position as a new standard of care.
- Safety Assessment: The incidence of grade ≥3 adverse events was 91.2% in ZUMA-7 and 88.7% in ALYCANTE, demonstrating a balance between the safety and efficacy of Yescarta.
- Clinical Significance: The findings from Yescarta's studies underscore its importance in difficult-to-treat patients, potentially altering treatment strategies and improving patient quality of life and prognosis.
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Analyst Views on GILD
Wall Street analysts forecast GILD stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for GILD is 133.83 USD with a low forecast of 105.00 USD and a high forecast of 150.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
20 Analyst Rating
17 Buy
3 Hold
0 Sell
Strong Buy
Current: 122.620
Low
105.00
Averages
133.83
High
150.00
Current: 122.620
Low
105.00
Averages
133.83
High
150.00
Truist
Gregory Renza
Buy
downgrade
$145 -> $140
2025-11-24
Reason
Truist
Gregory Renza
Price Target
$145 -> $140
2025-11-24
downgrade
Buy
Reason
Truist analyst Gregory Renza assumed coverage of Gilead with a Buy rating with a price target of $140, down from $145. The firm is positive on the continued strength for the company's HIV franchise, supported by Biktarvy's patent settlement and positive momentum across next-generation programs,most notably Yeztugo's PrEP launch and Bic/Len's positive phase 3 readout, pointing to a healthy outlook into the next-decade, the analyst tells investors in a research note. Truist adds that it also views the oncology franchise as a key growth pillar led by Trodelvy and anito-cel, further noting that Livdelzi's launch in PBC - Primary Biliary Cholangitis - is off to a strong start.
BMO Capital
BMO Capital
Outperform
maintain
$135
2025-11-24
Reason
BMO Capital
BMO Capital
Price Target
$135
2025-11-24
maintain
Outperform
Reason
BMO Capital says Phase 1 data from three patients in Kelonia Therapeutics' inMMyCAR study "look interesting," with all patients reaching MRD negativity by month one, but adds that the extremely small sample size and limited amount of patient follow-up "muddies comparisons" to Gilead (GILD) and Arcellx's (ACLX) anito-cel program. The tolerability profile of Kelonia's KLN-1010 "looks relatively clean," but the small sample size and the limited amount of patient follow-up "leave significant questions," adds the analyst, who keeps an Outperform rating and $135 price target on Gilead shares.
Mizuho
Outperform
maintain
$131 -> $140
2025-11-20
Reason
Mizuho
Price Target
$131 -> $140
2025-11-20
maintain
Outperform
Reason
Mizuho raised the firm's price target on Gilead to $140 from $131 and keeps an Outperform rating on the shares. The firm raised its price target primarily due to: Biktarvy's loss of exclusivity in the U.S. now expected to be 2036 instead of 2033 post generic lititgation settlements; the total addressable market for PrEP could be much larger than currently appreciated, and; the firm now models roughly 5% growth for Gilead's HIV business overall, from roughly 3% prior.
Scotiabank
NULL -> Outperform
initiated
$140
2025-11-12
Reason
Scotiabank
Price Target
$140
2025-11-12
initiated
NULL -> Outperform
Reason
Scotiabank initiated coverage of Gilead with an Outperform rating and $140 price target.
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About GILD
Gilead Sciences, Inc. is a biopharmaceutical company. It is engaged in advancing medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis, COVID-19, cancer, and inflammation. It is focused on discovering, developing, and delivering medicines to address unmet medical needs in virology, oncology, and other therapeutic areas. Its portfolio of marketed products includes Biktarvy, Genvoya, Descovy, Complera/Eviplera, Symtuza, Truvada, Stribild, Sunlenca, Epclusa, Vemlidy, Harvoni, Viread, Livdelzi, Veklury, Yescarta, Tecartus, Trodelvy, AmBisome, and Letairis. Its product candidates include Bulevirtide, Lenacapavir, Axicabtagene ciloleucel, Sacituzumab govitecan-hziy, and others. It also develops the HB-400 program and the HB-500 program. It develops therapies that are intended to provide functional cures for hepatitis B virus and human immunodeficiency virus-1. It has a cancer program, namely TREX1. It operates in more than 35 countries worldwide.
About the author
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Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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