Clearmind Signs Research Agreement with Hebrew University
Clearmind Medicine announced the signing of a new research agreement with Yissum Research Development Company of the Hebrew University of Jerusalem. The agreement will fund a preclinical study evaluating the metabolic efficacy of MEAI, both in combination with and as a maintenance therapy following tirzepatide treatment in diet-induced obese mice. The research will be conducted by Professor Joseph Tam and his team at the Obesity and Metabolism Laboratory at the Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem. These therapies have significantly advanced the treatment of obesity and type 2 diabetes, delivering substantial weight loss and cardiometabolic improvements. Despite their remarkable success, GLP-1 and dual GLP-1/GIP receptor agonists primarily work by suppressing appetite and reducing energy intake. A major clinical challenge remains: substantial weight regain- often 25% or more of the lost weight within one year, along with partial reversal of metabolic benefits, frequently occurs upon discontinuation. Building on results from its prior collaboration with Professor Yossi Tam's laboratory at the Hebrew University, where MEAI demonstrated approximately 15%-20% body weight reduction in DIO mice, primarily through increased energy expenditure and fat utilization while preserving lean mass and improving glucose homeostasis and hepatic steatosis, Clearmind is now advancing MEAI into combination and sequencing strategies with today's leading incretin therapy.
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- Clinical Trial Approval: Clearmind Medicine Inc. announced that its CMND-100 Phase I/II clinical trial has received approval from the Johns Hopkins Medicine Institutional Review Board, marking a significant advancement in the company's efforts to address alcohol use disorder and is expected to facilitate the smooth progression of subsequent research.
- Research Phase Progress: This approval allows the company to proceed with Parts B and C of the trial, reflecting the solid foundation laid by Clearmind's earlier successes at one of the world's leading clinical research institutions, which is crucial for future studies.
- CEO Commentary: CEO Dr. Adi Zuloff-Shani stated that this IRB approval represents an important step in the company's clinical development program, demonstrating confidence in the potential of its non-hallucinogenic MEAI-based candidate for patients suffering from alcohol use disorder, thereby enhancing market expectations for its products.
- Intellectual Property Strategy: Clearmind currently holds 19 patent families and 31 granted patents, with plans to seek additional patents in the future to strengthen its competitive position in the neuroplastogen drug sector and ensure the market standing of its innovative therapeutics.
- Reverse Stock Split Plan: Clearmind Medicine has announced a 1-for-10 reverse stock split effective May 21, 2026, aimed at regaining compliance with the Nasdaq Minimum Bid Price Rule, which will reduce the number of issued and outstanding common shares from 10,190,337 to approximately 1,019,033, thereby increasing the share price to meet compliance requirements.
- Market Reaction: Following the reverse split announcement, Clearmind's shares fell by 20% in premarket trading, indicating market concerns about the company's future prospects, which could undermine investor confidence and exacerbate liquidity risks.
- Compliance Pressure: This reverse stock split is a response to Nasdaq compliance pressures, as failure to restore the share price within the stipulated time frame could lead to delisting risks, posing significant challenges to the company's long-term development.
- Strategic Implications: By implementing the reverse stock split, Clearmind aims to attract more institutional investors by increasing its share price, thereby enhancing market recognition and creating conditions for future financing, although short-term price volatility may increase.
- Reverse Stock Split: Clearmind Medicine Inc. announced a 1-for-10 reverse stock split effective May 21, 2026, aimed at regaining compliance with Nasdaq's Minimum Bid Price Rule, which will reduce the number of outstanding shares from 10,190,337 to approximately 1,019,033, thereby potentially increasing the share price to meet listing requirements.
- Board Approval: The reverse split was approved by the company's board on March 18, 2026, reflecting proactive measures taken in response to stock price pressures, aimed at boosting investor confidence and maintaining its position in the capital markets.
- No Fractional Shares: Following the reverse split, no fractional shares will be issued, with all fractions rounded up to the nearest whole share, simplifying the shareholder structure and reducing potential shareholder confusion.
- Intellectual Property Strategy: Clearmind currently holds 19 patent families and 31 granted patents, with plans to seek additional patents in the future to enhance its market competitiveness in the non-hallucinogenic drug sector, demonstrating the company's commitment to innovation and intellectual property.
- Summit Participation: Clearmind Medicine's CEO, Dr. Adi Zuloff-Shani, was appointed as a delegate to the 2026 Federal Policy Summit held on May 14 in Washington, D.C., aimed at fostering dialogue between the biopharma industry and policymakers to advance the responsible development of psychedelic therapies.
- Clinical Trial Progress: Clearmind is advancing its non-hallucinogenic psychedelic candidate, currently undergoing Phase IIa clinical trials at leading institutions like Johns Hopkins and Yale, which not only showcases the company's commitment to innovative drug development but also addresses significant unmet health needs.
- Intellectual Property Strategy: Clearmind holds 19 patent families and 31 granted patents, with plans to seek additional patents as warranted, indicating a proactive approach to intellectual property that aims to enhance its market competitiveness and technological barriers.
- Industry Collaboration and Impact: The summit brought together key figures from the U.S. Congress and global biopharma CEOs, emphasizing the importance of cross-sector collaboration, and Clearmind's participation may pave the way for future policy support and market access.

- Clinical Trial Progress: Clearmind Medicine is evaluating its candidate CMND-100 for eligibility for the FDA's Breakthrough Therapy Designation based on positive results from its ongoing Phase I/IIa clinical trial for Alcohol Use Disorder, indicating significant therapeutic potential that could open new market opportunities for the company.
- Policy Support: The recent Executive Order signed by President Trump accelerates FDA review processes for certain breakthrough therapies, providing favorable conditions for CMND-100's application and further enhancing Clearmind's strategic position in the competitive biotech market.
- Market Demand: Alcohol Use Disorder represents a serious health issue affecting millions globally with limited treatment options, and the successful development of CMND-100 could address this substantial unmet medical need, potentially yielding significant economic benefits for the company.
- Intellectual Property Strategy: Clearmind currently holds 19 patent families and 31 granted patents, with plans to continue expanding its intellectual property portfolio to support drug development and commercialization strategies, ensuring a competitive edge in future market dynamics.








